Genes, Environment, and Psychopathology

Understanding the Causes of Psychiatric and Substance Use Disorders

Kenneth S. Kendler and Carol A. Prescott

November 7, 2007
ISBN 9781593856458
Price: $41.00 $30.75
412 Pages
Size: 6⅛" x 9¼"
Copyright Date: 2006


I. Background

1. The Scientific and Social Context of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders

2. Methodology Used in the VATSPSUD

3. Twinning and Twin Models

II. Genetic Risk

4. Internalizing Disorders

5. Externalizing and Substance Use Disorders

6. Twin Model Assumptions

III. Environmental Risk

7. Childhood Experiences and Risk for Psychopathology

8. Adult Experiences and Risk for Psychopathology

IV. A Closer Look at Genetic and Environmental Influences

9. Sex Differences

10. Genetic and Environmental Influences on Stability and Change

11. The Genetics of What?: Comorbidity, General versus Specific Effects, and Risk Indicators

12. Three Extensions of the Twin Model

V. Bringing it All Together

13. The Genetics of the Environment

14. Mechanisms for Genetic Control of Exposure to the Environment

15. Is the Relation between Environmental Risk Factors and Psychiatric Disorders Causal?

16. Genetic Control of Sensitivity to the Environment

17. Integrative Models

18. Conclusions


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