Genes, Environment, and Psychopathology

Understanding the Causes of Psychiatric and Substance Use Disorders

Kenneth S. Kendler and Carol A. Prescott

November 7, 2007
ISBN 9781593856458
Price: $41.00
412 Pages
Size: 6⅛" x 9¼"
Copyright Date: 2006

“A good general introduction to twin-family research on psychopathology....This book is a valuable reference for those working in the field of psychiatric genetics, whether experienced researchers or students. Even for genetic epidemiologists with little interest in psychopathology, this book provides an excellent case study of a large-scale twin-family research project and the type of hypotheses that can be explored with the data such studies provide. Thanks to the well-structured and easily understandable writing style that Kendler and Prescott use, this book will also have relevance for those with no knowledge of behavioral genetics but an interest in psychiatry or substance abuse.”

Drug and Alcohol Review

“This book is a gem. It takes the reader on a behind-the-scenes excursion into the rationale, methodology, and findings of one of the most ambitious and influential genetic-epidemiological studies in recent history....Kendler and Prescott clearly aim to make their reasoning and methods accessible, and they succeed. They also go to considerable effort to make the book reader-friendly....Rarely does a reader have such an opportunity to be exposed to the kind of thoughtful, deliberative planning that goes into every aspect of the design and implementation of a study. Equally compelling is the way the reader is guided through how to distinguish between various causal explanations and how specific features of the study design make it possible to answer certain questions....The book presents a dazzling array of findings that both clinicians and researchers will be eager to know.”

American Journal of Psychiatry

“Clear, thoughtful, and timely....This book is a gift to all those willing to embrace the underlying complexity of psychiatric disorders and substance abuse.”

Twin Research and Human Genetics

“The only thing I disagree with in this book is the authors' statement that there is no such thing as a definitive study—this is a definitive study! The authors present impressive findings about mental illness and drug use from research on a very large sample of adult twins studied over time. The book provides convincing evidence for the importance of genetics in psychopathology, but goes far beyond 'nature versus nurture.' Most interestingly, it is about the interplay between nature and nurture. It offers a nuanced perspective that should be required reading for anyone interested in the causes of mental illness.”

—Robert Plomin, PhD, Institute of Psychiatry, London, United Kingdom

“This very readable and most engaging book by world leaders in psychiatric genetics is an essential read. The book is based on one of the best twin studies of common adult psychopathology that has been done. It is really good to have the findings brought together in such an interesting way. But the book is much, much more than that. It provides an exceptionally clear understanding of the rationale and logic involved in multivariate genetic statistical modeling, and an equally lucid understanding of how this may be used to tackle vitally important questions about mental disorder. Most of all, it provides a lively, balanced, informative conceptual understanding of how genes and environment work together in causal pathways as they operate over time.”

—Michael Rutter, MD, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom

“Written in an informal, readable style, this unique text offers insight into the process of the world-renowned Virginia Adult Twin Study, and provides the opportunity to review the many important results that have emerged from this work. Readers will gain a better understanding of how genetic and environmental factors operate in complex psychiatric disorders, while also observing how hypotheses can be developed and tested. For students, the straightforward and highly informative details of the methods used to test major and ancillary questions will be particularly valuable. Scientists, for their part, will benefit from having a single, well-referenced source on this excellent study.”

—Marc A. Schuckit, MD, Department of Psychiatry, University of California, San Diego; Alcohol Research Center, VA San Diego Healthcare System

“Over the last 20 years, it is likely that no other single study has had a greater impact on academic psychiatry than the Virginia Adult Twin Study, which has been instrumental in ushering in the current genomics era in biological psychiatry. Kendler and Prescott have done the field an immeasurable service by placing the major findings from the study under a single cover. But this book is much more than a summary of their voluminous research record: it provides a methodological primer, discusses the challenges of observational science, and speculates on the future of psychiatric genetics. As such, it should be equally useful for the seasoned researcher interested in a concise summary of this important project and for the student who seeks an accessible introduction to the field.”

—Matt McGue, PhD, University of Minnesota